The roles functions and researches of the p53 gene and how it can help in fighting cancer

Cancer Research: Understanding the p53 Gene

When the resin of Boswellia frereana is burned on a hot coal, you will notice that the resin literally melts into the coal, leaving behind little-to-no gum residue.

She elaborated that the human genome is comprised of some 30, genes, which are present in each individual human cell. An oncogene could be compared with a gas pedal that is stuck down, which causes the cell to divide out of control.

From highest to lowest they are Hojari, Najdi, Shazri, and Shabi. The oleo-gum-resin The yellow resin of Boswellia Dalzielli is used to treat the kidneys and to act as a diuretic. For example, p14ARF can detect various senescence signals, and by binding Mdm2, can activate p Incensole and incensole acetate have a couple of interesting properties.

Mutant p53 can no longer bind DNA in an effective way, and as a consequence the p21 protein is not made available to act as the 'stop signal' for cell division. In several other studies, the contribution of the transcriptional activation function of p53 to peffector functions was probed.

Consequently, there is an ever-growing list of p53 targets and effector functions. J Cell Physiol The Boswellia dalzielii tree is usually found in the savannas of Western Africa, growing up to about 13 meters in height. An important difference between oncogenes and tumor suppressor genes is that oncogenes result from the activation turning on of proto-oncogenes, but tumor suppressor genes cause cancer when they are inactivated turned off.

The permanent cell-cycle arrest program that accompanies senescence is considered most pertinent to its putative tumor suppressive role.

The aforementioned section describes several processes that might contribute to p53 tumor suppressor activity; thereby raising the question of which ones or one are crucial. Despite a significant body of literature detailing the biochemical and biological functions of p53, much remains to be elucidated.

The gum is very soft and not as sticky compared to other frankincense resins.

Oncogenes and tumor suppressor genes

So how is Boswellia papyrifera related to MS. That means these plants may be able to provide you effects similar to incensole and incensole acetate found in the Boswellia papyrifera frankincense. When this happens to me, I either eat some food to remove the sticky residue, or add some less-sticky more-brittle gum resin to chew.

Tumor Suppressive Functions of p53

Courtesy of African plants — A Photo Guide. Jun 25,  · Two of the main types of genes that play a role in cancer are oncogenes and tumor suppressor genes.

Breakthrough research answers mysteries behind vital cancer-suppressing gene

Learn more here. Proto-oncogenes are genes that normally help cells grow. When a proto-oncogene mutates (changes) or there are too many copies of it, it becomes a "bad" gene that can become permanently turned on or activated when.

Capitalizing on a mutant p53 gene to fight pancreatic cancer. The p53 gene has long held interest in the oncology research community because of its proven role as producer of a tumor.

A team from the Wellcome Trust Sanger Institute has found a major piece of biological evidence to support the role a group of virus-fighting genes has in cancer development. The p53 gene is a gene that codes for a protein that inhibits the development and growth of tumors (in addition to other functions).

It is known as a tumor suppressor gene. If this gene is mutated—that is, altered in some way by either the environment or inheritance, damaged cells are allowed to survive, and ultimately, develop into cancer cells.

The Genetics of Cancer; Request Permissions. The Genetics of Cancer.

A common Gain of function of p53 cancer mutants in inducing genetic instability

The most commonly mutated gene in people with cancer is p53 or TP More than 50% of cancers involve a missing or damaged p53 gene. This further complicates our understanding of the role genes play in cancer.

Strengthen your p53 Genes. Epigenetic factors are clearly responsible for increasing your risk of developing fatal cancers. While the genetics you inherited from your parents do play a role in health, the influence from epigenetic factors is one of the greatest factors which can both help or harm your p53 genes.

The roles functions and researches of the p53 gene and how it can help in fighting cancer
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Tumor Suppressive Functions of p53